suppositories?

I happen to have a box. The principal ingredient (88%) is cocoa butter. So, I suppose use as a pre-lube could be considered. However, there are other ingredients that may not be needed nor desirable. Perhaps some Aneros 'experts' can weigh in?

As @goldenboy notes, most of the commercial suppositories have a lubricant, some have an astringent to shrink the tissue and perhaps a topical anesthetic or analgesic. Numbing the sensory nerves in the anus, anal canal and rectum might impede orgasmic progress.

That said, some Forum members blend their own anal lube from bulk unrefined materials like Shea Butter, Coconut Oil, Cocoa Butter, Beeswax, etc. When the weather is warm that blend can be injected using simple "lube shooters" In the winter it's easier to apply when formed into suppositories and each is slid through the anal canal. Suppositories make it easy to measure the amount of lube. Guys who make suppositories have chosen from a wide variety of molding forms such as bullet molds (9mm is a nice size, etc.) or, novelty ice cube trays.

@Xochipelli has a very complete thread posted in the old Forum. (search for Shea Butter suppositories.)

You can also use the same search string in Google to view a wide range of additive substances to alter the character or your session.