First time poppers

Your first time you should try it while your just jacking to see what the feeling is like. I use them, and wow what a sexual rush u get from this stuff, but is is a short lived rush

Can you explain exactly what a popper is and what they do?

My question is, should I try them for the very first time when I'm in a session (or even just masturbating) or should I try them beforehand so I know what it feels like?...so maybe you can give me some advice on that.

It's your body to do with as you wish but you might also want to read what a couple of Aneros veterans (@darwin & @B Mayfield) had to say 10 years ago in this thread -> question about poppers. and outside forum conversations.. Experimentation with chemical substances always carries some risks, becoming well informed about the chemical you intend to ingest may alter your decision to even try it at all. Here's a link to information/experiences with various 'inhalants', please educate yourself before trying.
Good Vibes to You !

It's kinda scary what it feels like the first time. Your face feels hot and flush, your heart pounds (or at least you become more aware of it beating), and your head and muscles feel like you're trying to move through tapioca.

Like the others say, research the chems before you start to use them. Amyl nitrite was the chemical originally used for poppers. It was a vascular dilator, medication to treat heart and blood flow issues. Isopropyl Nitrite is probably what you'll find in those small bottles labeled "Head Cleaner". It has mostly the same effect, pushing more blood to the brain.

The main safety issue with Isopropyl nitrite is the vapours. They're highly flammable, and tend to hang around in poorly ventilated rooms. The vapours are the primary intake, you just need to breathe them in to get them to work. That means mouth or nose, it's equally effective through either route. When I tried it, I poured the bottle out in a ziploc bag I'd stuffed with paper towels, and that was way more than enough to get things going.

Like with anything else that's unsafe you're trying for the first time, don't do it alone. Have a "buddy" there with you.

Please be careful with this kind of thing. Don't EVER mix it with viagra, it can lower your blood pressure dangerously. For the sake of harm reduction, please read up on it so you don't accidentally hurt yourself.