Question regarding failures after multiple attempts.

... is it possible that in men who fail to orgasm after multiple attempts that they have built a neural pathway that is resulting in the brain telling the prostate to turn itself off to stimulation attempts?

What you are postulating is a form of self inflicted aversion therapy (the movie A Clockwork Orange comes to mind). I suppose it would be possible in a masochistic individual suffering from cognitive dissonance or some similar psychological condition. However, I think this would be pretty rare. I think it is more likely a particular individual's lack of success has more to do with dealing with issue(s) listed in the thread Identifying Obstacles to Progress.
Good Vibes to You !

@rumel when you say masochistic... you don’t mean sexually, I assume?

Because sexual masochism is often the pursuit of pain for those for who find sexual pleasure in it. I just saw on your Wikipedia link that there exists a masochistic personality disorder (which I imagine you are referencing). As someone with masochistic sexual tendencies, I find that to be semantically confusing. Pain for me is as pleasureful as caresses, tickling, and everything sweet. There is nothing self-defeating or inherently negative in sexual masochism. In fact, anyone masochistic will tell you that enjoying pain and humiliation and everything related to it is simply using our nerves and brains to the maximum of their sexual capacities.

however the various masochistic personality disorders listed sound awful and really unhealthy. This use of the word masochism for something so negative really irks me...

First, full disclosure, I'm am not a psychologist or a doctor, I'm just a layman with an interest in human psychology and associated behaviors. Anything I post in this Forum is just my opinion based upon my understanding of my world reality experiences and learning. I fully recognize that every individual is experiencing their world reality uniquely different from mine though we all share a commonality of physical existence. It is in the nuanced interpretation of personal perceptions that our realities can markedly differ.

As someone with masochistic sexual tendencies, I find that to be semantically confusing. Pain for me is as pleasureful as caresses, tickling, and everything sweet. There is nothing self-defeating or inherently negative in sexual masochism.

I was referencing masochism in the more general sense though that can include sexual practices. I wasn't implying any positive or negative judgement about the inclination toward masochistic practices, perhaps I should have not even mentioned masochism. My main point was to highlight cognitive dissonance as a more likely cause for lack of success in one's Aneros journey rather than self programming on a neural level via aversion therapy like techniques.

In fact, anyone masochistic will tell you that enjoying pain and humiliation and everything related to it is simply using our nerves and brains to the maximum of their sexual capacities.

I have no disagreement with that statement nor do I assign any positive or negative judgement to practitioners.

however the various masochistic personality disorders listed sound awful and really unhealthy. This use of the word masochism for something so negative really irks me...

I think it is possible that any practice, masochistic or otherwise, when taken to extremes can become unhealthy both physically and psychically. I think it is sad if that happens and that would irk me as well.
Good Vibes to You !

I think I may have been.. strongly suggested of me... that I may have this dissonance, what's the way to fix oneself, if cognitive dissonance exists within yourself?

it is about alignment of behaviors with beliefs. when behavior is not in sync with beliefs you have cognitive dissonance. the only way to fix it is get your behaviors in line with beliefs or change your beliefs as they relate to a behavior.

problem is...throw a dose of denial about either the belief or behavior into it, and you really have to spend time first fixing that before even addressing the dissonance. I have been thinking about how denial may be playing into cognitive dissonance and lack of response from massage all day today.

@rumel got it. I know you weren’t ragging on masochism. I guess I am bummed to find out that masochism has such a bad rap as to lend its name to a serious disorder. For me the term masochism implies a spectrum of indescribable pleasures, pleasures that the layman cannot conceive of. Thus the layman only sees pain and suffering.

English and many other languages display similar misuse of terms, which can marginalize groups of people based on their sexuality. Common examples in English are: “that’s gay”, marginalizing homosexuals; the negative connotations of the verb fuck, for example, “you got fucked” to mean you got swindled, which highlights the our societies negative view of being penetrated, thus marginalizing the penetrated (women and... surprise, surprise, men who partake in anal play); more subtly, “man up” or “be a man”, which marginalizes those for whom masculinity is not about bravado or hiding true emotions behind a stoic facade; or “don’t be a pussy/pansy”.

Here in France, a common insult is “enculé” which means “sodomized person”. Imagine the subtle impact of that on men into anal play (or not into anal play, rather, because of societal norms and the commoness of this sort of language).

sorry for the long rant unrelated to the topic! Sometimes I write here on this forum to clarify my own ideas on life and sexuality 🙂