Rewired means

Good though to pick your 'poison' from something that won't leave you physically dependent.

Good to just stick with the pleasure your own brain produces. Then visit another day.

I like to think that plants and mushrooms and the like have a symbiotic relationship with beings like ourselves with consciousness, that their 'consciousness' is expressed thru us when we consume them.
The tinkering that goes on when humans play God presuming that chemical knowledge is sufficient to (re)create lacks this (unmeasurable) property.
The natural products that are addictive like heroine, cocaine etc have been chemically enhanced to make more potent. Hallucinogenics like LSD are very different in nature than the natural kind.

The main thing about the drugs I mean though is that they have an arousing element to them, drugs that otherwise might scare you or give a bad trip. It's just good to know that you can re- route this into orgasm energy AND experience the psychedelic properties as well.
And they feed on each other because your state of mind is positively impacted by the strength of the orgasm